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Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 564-582 doi: 10.1007/s11684-019-0724-6

Abstract: Berberine, an isoquinoline alkaloid isolated from the Chinese herb and other plants, has a wide range of pharmacological properties. Berberine can be used to treat many diseases, such as cancer and digestive, metabolic, cardiovascular, and neurological diseases. Berberine has protective capacities in digestive diseases. It can inhibit toxins and bacteria, including , protect the intestinal epithelial barrier from injury, and ameliorate liver injury. Berberine also inhibits the proliferation of various types of cancer cells and impedes invasion and metastasis. Recent evidence has confirmed that berberine improves the efficacy and safety of chemoradiotherapies. In addition, berberine regulates glycometabolism and lipid metabolism, improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. Berberine shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Furthermore, berberine exerts protective effects against other diseases. The mechanisms of its functions have been extensively explored, but much remains to be clarified. This article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive, metabolic, cardiovascular, and neurological diseases.

Keywords： berberine     Coptis chinensis     pharmacological properties     mechanism     clinical applications    

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Current applications of artificial intelligence for intraoperative decision support in surgery

Allison J. Navarrete-Welton, Daniel A. Hashimoto

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 369-381 doi: 10.1007/s11684-020-0784-7

Abstract: medical artificial intelligence (AI) has made significant advances in recent years, including surgical applicationsmethodological shortcomings were observed in most of the reviewed papers that made it difficult to assess the clinical

Keywords： artificial intelligence     decision support     clinical decision support systems     intraoperative     deep learning    

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Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 562-574 doi: 10.1007/s11684-020-0771-z

Abstract: The protection of language function is one of the major challenges of brain surgery. Over the past century, neurosurgeons have attempted to seek the optimal strategy for the preoperative and intraoperative identification of language-related brain regions. Neurosurgeons have investigated the neural mechanism of language, developed neurolinguistics theory, and provided unique evidence to further understand the neural basis of language functions by using intraoperative cortical and subcortical electrical stimulation. With the emergence of modern neuroscience techniques and dramatic advances in language models over the last 25 years, novel language mapping methods have been applied in the neurosurgical practice to help neurosurgeons protect the brain and reduce morbidity. The rapid advancements in brain–computer interface have provided the perfect platform for the combination of neurosurgery and neurolinguistics. In this review, the history of neurolinguistics models, advancements in modern technology, role of neurosurgery in language mapping, and modern language mapping methods (including noninvasive neuroimaging techniques and invasive cortical electroencephalogram) are presented.

Keywords： neurolinguistics     language mapping     dual pathway model     neurosurgery    

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Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy Review

Feng Xie, Rui Liang, Dan Li, Bin Li

Engineering 2019, Volume 5, Issue 1,   Pages 132-139 doi: 10.1016/j.eng.2018.12.002

Abstract: indicates a poorer prognosis; therefore, there is renewed interest in the function of Tregs and in their clinical

Keywords： Regulatory T cells     Cancer     Immunotherapy    

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Progress of Brain Network Studies on Anesthesia and Consciousness: Framework and Clinical Applications Review

Jun Liu, Kangli Dong, Yi Sun, Ioannis Kakkos, Fan Huang, Guozheng Wang, Peng Qi, Xing Chen, Delin Zhang, Anastasios Bezerianos, Yu Sun

Engineering 2023, Volume 20, Issue 1,   Pages 77-95 doi: 10.1016/j.eng.2021.11.013

Abstract: We demonstrate that whole-brain multimodal network data can provide important supplementary clinicalthat brain network methods, if simplified, will likely play an important role in improving the current clinical

Keywords： Anesthesia     Brain network     Connectivity     Graph theoretical analysis     Clinical monitoring system    

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Organoid Technology and Clinical Applications in Digestive System Cancer Review

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Engineering 2022, Volume 9, Issue 2,   Pages 123-130 doi: 10.1016/j.eng.2021.04.017

Abstract: critical features of the original tumor, resulting in the failure of translation from basic research into clinicalIn this review, we summarize the general methods to generate human DS organoids and their applications

Keywords： Organoid     Digestive system cancer     Precision medicine    

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Special issue: Innovative applications of big data and artificial intelligence

Frontiers of Engineering Management 2022, Volume 9, Issue 4,   Pages 517-519 doi: 10.1007/s42524-022-0234-0

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Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 358-361 doi: 10.1007/s11684-014-0348-9

Abstract:

This study proposes the ontological reconstruction of the current clinical terminology of traditionalof preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinicalWe conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation

Keywords： ontology     traditional Chinese medicine     clinical terminology    

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Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Review

Bruce R. Blazar

Engineering 2019, Volume 5, Issue 1,   Pages 98-105 doi: 10.1016/j.eng.2018.11.016

Abstract: with GVHD outcomes that focus exclusively on immune regulatory cell therapies that have progressed to clinical

Keywords： Graft-versus-host disease (GVHD)     Immune regulatory cells     Cell therapy    

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The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 527-533 doi: 10.1007/s11684-022-0967-5

Abstract: In this study, we aim to elucidate the clinical impact and long-term course of tricuspid regurgitation

Keywords： orthotopic heart transplant     tricuspid regurgitation     clinical impact     biatrial heart transplantation    

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Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 340-348 doi: 10.1007/s11684-017-0570-3

Abstract: A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of

Keywords： obesity-related glomerulopathy     pathogenesis     pathologic     clinical characteristics    

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Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 126-135 doi: 10.1007/s11684-020-0767-8

Abstract: promising antivirals, convalescent plasma transfusion, and tocilizumab needs to be investigated by ongoing clinical

Keywords： coronavirus disease 2019     epidemiology     pathology     radiology     clinical characteristics     treatment    

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Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 307-309 doi: 10.1007/s11684-017-0578-8

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Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 551-573 doi: 10.1007/s11684-022-0928-z

Abstract: Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

Keywords： HCC     bone     osteotropism     clinical     basic researches     advances    

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Heterogeneity of the tumor immune microenvironment and clinical interventions

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 617-648 doi: 10.1007/s11684-023-1015-9

Abstract: Heterogeneity of the tumor immune microenvironment and clinical interventions

Keywords： Heterogeneity tumor immune    

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Title Author Date Type Operation

Biological properties and clinical applications of berberine

Danyang Song, Jianyu Hao, Daiming Fan

Journal Article

Current applications of artificial intelligence for intraoperative decision support in surgery

Allison J. Navarrete-Welton, Daniel A. Hashimoto

Journal Article

Clinical applications of neurolinguistics in neurosurgery

Peng Wang, Zehao Zhao, Linghao Bu, Nijiati Kudulaiti, Qiao Shan, Yuyao Zhou, N. U. Farrukh Hameed, Yangming Zhu, Lei Jin, Jie Zhang, Junfeng Lu, Jinsong Wu

Journal Article

Regulatory T Cells and Their Clinical Applications in Antitumor Immunotherapy

Feng Xie, Rui Liang, Dan Li, Bin Li

Journal Article

Progress of Brain Network Studies on Anesthesia and Consciousness: Framework and Clinical Applications

Jun Liu, Kangli Dong, Yi Sun, Ioannis Kakkos, Fan Huang, Guozheng Wang, Peng Qi, Xing Chen, Delin Zhang, Anastasios Bezerianos, Yu Sun

Journal Article

Organoid Technology and Clinical Applications in Digestive System Cancer

Xiaofang Zhao, Youhai Jiang, Chunliang Liu, Minghui Hou, Hongyang Wang, Jing Fu

Journal Article

Special issue: Innovative applications of big data and artificial intelligence

Journal Article

Ontological reconstruction of the clinical terminology of traditional Chinese medicine

Li Ma,Baoyan Liu,Qi Xie,Shusong Mao,Zhiwei Cui

Journal Article

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host

Bruce R. Blazar

Journal Article

The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant

Journal Article

Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment

Tianhua Xu, Zitong Sheng, Li Yao

Journal Article

Coronavirus disease 2019 (COVID-19): a clinical update

Min Zhou, Xinxin Zhang, Jieming Qu

Journal Article

Hypertension in patients with CKD in China: clinical characteristics and management

Guangyan Cai, Xiangmei Chen

Journal Article

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

Journal Article

Heterogeneity of the tumor immune microenvironment and clinical interventions

Journal Article